Neural Cell Adhesion Molecule N-cam Inhibits Astrocyte Proliferation After Injury To Different Regions Of The Adult Rat Mind Pmc
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- Logan A, Frautschy SA, Gonzalez AM, Baird A. A time course for the focal elevation of synthesis of primary fibroblast progress issue and considered one of its high-affinity receptors following a localized cortical brain damage.
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- We persistently discovered that the population of dividing astrocytes was significantly smaller on the side during which N-CAM or one of many N-CAM-related molecules was infused than on the opposite side.
After a penetrating lesion in the central nervous system, astrocytes enlarge, divide, and participate in creating an setting that adversely affects neuronal regeneration. We have just lately proven that the neural cell adhesion molecule (N-CAM) partially inhibits the division of early postnatal rat astrocytes in vitro. Animals had been lesioned in the cerebral cortex, hippocampus, or striatum with a Hamilton syringe and needle at defined stereotaxic positions. On one side, the lesions had been concomitantly infused with N-CAM or with one of many N-CAM-related molecules.
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Miyake T, Hattori T, Fukuda M, Kitamura T. Reactions of S-100-positive glia after damage of mouse cerebral cortex. Miyake T, Hattori T, Fukuda M, Kitamura T, Fujita S. Quantitative studies on proliferative changes of reactive astrocytes in mouse cerebral cortex. Kniss DA, Burry RW. Serum and fibroblast growth factor stimulate quiescent astrocytes to re-enter the cell cycle. Hunter KE, Ssex MB, Davies AM. Transforming development factor-betas inhibit mitogen-stimulated proliferation of astrocytes. Topp KS, Faddis BT, Vijayan VK. Trauma-induced proliferation of astrocytes in the brains of young and aged rats.
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